tissueResolver is a package for converting bulk RNA-seq datasets into virtual tissues using information from similar single cell datasets by assigning weights to true single cells, maintaining their molecular integrity. Virtual tissues can be analyzed in a similar way as conventional single cell datasets.
For details, see bioarxiv
Use devtools to install the package:
library(devtools)
devtools::install_github("spang-lab/tissueResolver")We provide a detailed vignette reproducing the results of our paper.
Virtual Tissue Expression Analysis by
Jakob Simeth, Paul Hüttl, Marian Schön, Zahra Nozari, Michael Huttner, Tobias Schmidt, Michael Altenbuchinger, Rainer Spang, 2023.
For preprint see bioarxiv