EndALS 2025 Validation Workflow

The repository contains the validation workflow for the EndALS 2025 Challenge.

Challenge Overview

The challenge is split into three tasks:

1. Subtyping and Pathway Analysis

   Participants must produce a list of clusters or subgroups in the ALS population, ordered by prevalence, and annotated with relevant pathways. These subgroups should be compared against control populations.

2. Clinical Symptom Trajectories

   Participants must generate a list of clinical symptoms reported in ALS patients, along with the average timeline and sequence of their appearance. This includes symptoms before and after diagnosis, and ordering relative to one another.

3. Genetic, Transcriptomic, and Clinical Features

   Participants must provide a list of genetic variants, transcripts, and clinical symptoms most prevalent in the ALS population. Submissions may also integrate combinations of these factors to reveal multimodal ALS signatures.

Validation Criteria

Coming soon