Using local downloaded JSON.gz files

Download from Github releases

You only need ONE of the combined 37/38 file or individual genome builds, not both.

Loading in HGVS libraries

You can pass a list of JSON.gz files to the HGVS loaders, eg to load both RefSeq and Ensembl:

local_json = [
    "./cdot-0.2.12.refseq.grch37_grch38.json.gz",
    "./cdot-0.2.12.ensembl.grch37_grch38.json.gz",
]
hdp = JSONDataProvider(local_json)