TCRdb(2.0): A comprehensive T-cell receptor sequences database

The unique features of TCRdb include:

• Comprehensive and reliable sequences for TCR repertoire in different samples generated by a strict and uniform pipeline of TCRdb;
• Powerful search function, allowing users to identify their interested TCR sequences in different conditions;
• Categorized sample metadata, enabling comparison of TCRs in different sample types;
• Interactive data visualization charts, describing the TCR repertoire in TCR diversity, length distribution and V-J gene utilization.

Newly Update

• A substantial increase in data volume, with the number of TCR samples growing from 8,265 to 19,701 and the number of TCR sequences expanding from 277 million to about 700 million
• Construction of the largest TCR reference in healthy samples, which contains 1,888 samples labeled as healthy controls from 40 published studies.
• New search function, supporting batch search.
• Redesigned download function

Description

CATT .smk, MiXCR.smk, IMSEQ.smk: The parameters used for each method.

Download.smk： For data download from NCBI (Deprecated in TCRdb 2.0).

QC_single/double.smk: For raw data quanlity control.

All the pipepines were written in Snakemake.

Citing

Si-Yi Chen, Tao Yue, Qian Lei, An-Yuan Guo, TCRdb: a comprehensive database for T-cell receptor sequences with powerful search function, Nucleic Acids Research, , gkaa796, https://doi.org/10.1093/nar/gkaa796

Tao Yue, Si-Yi Chen, Wen-Kang Shen, Yu Liao, Qian Lei, An-Yuan Guo, TCRdb 2.0: an updated T-cell receptor sequence database, unpublished

Access

The TCRdb database is freely available at https://guolab.wchscu.cn/TCRdb/

The latest TCRdb2.0 is freely available at https://guolab.wchscu.cn/TCRdb2.0/