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133 changes: 133 additions & 0 deletions models/AOP_10_orig.ttl
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@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xml: <http://www.w3.org/XML/1998/namespace> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix : <http://www.co-ode.org/ontologies/ont.owl#> .
@base <http://www.w3.org/2002/07/owl#> .

<https://noctua.apps.renci.org/model/AOP_10_orig> a owl:Ontology .
<https://noctua.apps.renci.org/model/AOP_10_orig> <http://purl.org/dc/elements/1.1/title> "Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain"^^xsd:string .
<https://noctua.apps.renci.org/model/10> <http://geneontology.org/lego/modelstate> "review"^^xsd:string .


#################################################################
# Classes
#################################################################

### http://purl.obolibrary.org/obo/CHEBI_17996
<http://purl.obolibrary.org/obo/CHEBI_17996> rdf:type owl:Class .

### http://purl.obolibrary.org/obo/GO_0022851
<http://purl.obolibrary.org/obo/GO_0022851> rdf:type owl:Class .

### http://purl.obolibrary.org/obo/GO_0051899
<http://purl.obolibrary.org/obo/GO_0051899> rdf:type owl:Class .

### http://purl.obolibrary.org/obo/NBO_0000025
<http://purl.obolibrary.org/obo/NBO_0000025> rdf:type owl:Class .

### http://purl.obolibrary.org/obo/PR_000007766
<http://purl.obolibrary.org/obo/PR_000007766> rdf:type owl:Class .

### http://purl.obolibrary.org/obo/GO_0050811
<http://purl.obolibrary.org/obo/GO_0050811> rdf:type owl:Class .

### http://purl.obolibrary.org/obo/PR_000007770
<http://purl.obolibrary.org/obo/PR_000007770> rdf:type owl:Class .

### http://purl.obolibrary.org/obo/PR_000007771
<http://purl.obolibrary.org/obo/PR_000007771> rdf:type owl:Class .

### http://purl.obolibrary.org/obo/GO_0007268
<http://purl.obolibrary.org/obo/GO_0007268> rdf:type owl:Class .

### http://purl.obolibrary.org/obo/GO_0060079
<http://purl.obolibrary.org/obo/GO_0060079> rdf:type owl:Class .



#################################################################
# Individuals
#################################################################

### http://www.co-ode.org/ontologies/ont.owl#gamma-aminobutyric%20acid%20receptor%20subunit%20alpha-1
<http://www.co-ode.org/ontologies/ont.owl#gamma-aminobutyric%20acid%20receptor%20subunit%20alpha-1> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/PR_000007766> ;
<http://purl.obolibrary.org/obo/RO_0002331> :GABA%20receptor%20binding ;
<http://purl.obolibrary.org/obo/RO_0002327> :GABA%20receptor%20binding ;
<http://purl.obolibrary.org/obo/RO_0002353> :GABA%20receptor%20binding ;
<http://purl.obolibrary.org/obo/RO_0002428> :GABA%20receptor%20binding .

### http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding
<http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/GO_0050811> ;
<http://purl.obolibrary.org/obo/RO_0002410> :GABA-gated%20chloride%20ion%20channel%20activity .

### http://www.co-ode.org/ontologies/ont.owl#gamma-aminobutyric%20acid%20receptor%20subunit%20alpha-5
<http://www.co-ode.org/ontologies/ont.owl#gamma-aminobutyric%20acid%20receptor%20subunit%20alpha-5> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/PR_000007770> ;
<http://purl.obolibrary.org/obo/RO_0002331> :GABA%20receptor%20binding ;
<http://purl.obolibrary.org/obo/RO_0002327> :GABA%20receptor%20binding ;
<http://purl.obolibrary.org/obo/RO_0002353> :GABA%20receptor%20binding ;
<http://purl.obolibrary.org/obo/RO_0002428> :GABA%20receptor%20binding .

### http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding
<http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/GO_0050811> ;
<http://purl.obolibrary.org/obo/RO_0002410> :GABA-gated%20chloride%20ion%20channel%20activity .

### http://www.co-ode.org/ontologies/ont.owl#gamma-aminobutyric%20acid%20receptor%20subunit%20alpha-6
<http://www.co-ode.org/ontologies/ont.owl#gamma-aminobutyric%20acid%20receptor%20subunit%20alpha-6> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/PR_000007771> ;
<http://purl.obolibrary.org/obo/RO_0002331> :GABA%20receptor%20binding ;
<http://purl.obolibrary.org/obo/RO_0002327> :GABA%20receptor%20binding ;
<http://purl.obolibrary.org/obo/RO_0002353> :GABA%20receptor%20binding ;
<http://purl.obolibrary.org/obo/RO_0002428> :GABA%20receptor%20binding .

### http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding
<http://www.co-ode.org/ontologies/ont.owl#GABA%20receptor%20binding> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/GO_0050811> ;
<http://purl.obolibrary.org/obo/RO_0002410> :GABA-gated%20chloride%20ion%20channel%20activity .

### http://www.co-ode.org/ontologies/ont.owl#chloride
<http://www.co-ode.org/ontologies/ont.owl#chloride> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/CHEBI_17996> ;
<http://purl.obolibrary.org/obo/RO_0002327> :GABA-gated%20chloride%20ion%20channel%20activity .

### http://www.co-ode.org/ontologies/ont.owl#GABA-gated%20chloride%20ion%20channel%20activity
<http://www.co-ode.org/ontologies/ont.owl#GABA-gated%20chloride%20ion%20channel%20activity> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/GO_0022851> ;
<http://purl.obolibrary.org/obo/RO_0002410> :chemical%20synaptic%20transmission .

### http://www.co-ode.org/ontologies/ont.owl#chemical%20synaptic%20transmission
<http://www.co-ode.org/ontologies/ont.owl#chemical%20synaptic%20transmission> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/GO_0007268> ;
<http://purl.obolibrary.org/obo/RO_0002410> :excitatory%20postsynaptic%20potential .

### http://www.co-ode.org/ontologies/ont.owl#excitatory%20postsynaptic%20potential
<http://www.co-ode.org/ontologies/ont.owl#excitatory%20postsynaptic%20potential> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/GO_0060079> ;
<http://purl.obolibrary.org/obo/RO_0002410> :membrane%20depolarization .

### http://www.co-ode.org/ontologies/ont.owl#membrane%20depolarization
<http://www.co-ode.org/ontologies/ont.owl#membrane%20depolarization> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/GO_0051899> ;
<http://purl.obolibrary.org/obo/RO_0019000> :seizures .

### http://www.co-ode.org/ontologies/ont.owl#seizures
<http://www.co-ode.org/ontologies/ont.owl#seizures> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/NBO_0000025> .



#################################################################
# Object Statements
#################################################################

<http://purl.obolibrary.org/obo/RO_0002327> rdf:type owl:ObjectProperty .
<http://purl.obolibrary.org/obo/RO_0002410> rdf:type owl:ObjectProperty .
<http://purl.obolibrary.org/obo/RO_0019000> rdf:type owl:ObjectProperty .
<http://purl.obolibrary.org/obo/RO_0002331> rdf:type owl:ObjectProperty .
<http://purl.obolibrary.org/obo/RO_0002353> rdf:type owl:ObjectProperty .
<http://purl.obolibrary.org/obo/RO_0002428> rdf:type owl:ObjectProperty .
203 changes: 203 additions & 0 deletions models/AOP_12_orig.ttl
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@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xml: <http://www.w3.org/XML/1998/namespace> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix : <http://www.co-ode.org/ontologies/ont.owl#> .
@base <http://www.w3.org/2002/07/owl#> .

<https://noctua.apps.renci.org/model/AOP_12_orig> a owl:Ontology .
<https://noctua.apps.renci.org/model/AOP_12_orig> <http://purl.org/dc/elements/1.1/title> "Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging"^^xsd:string .
<https://noctua.apps.renci.org/model/12> <http://geneontology.org/lego/modelstate> "review"^^xsd:string .


#################################################################
# Classes
#################################################################

### http://purl.obolibrary.org/obo/GO_0017146
<http://purl.obolibrary.org/obo/GO_0017146> rdf:type owl:Class .

### http://purl.obolibrary.org/obo/GO_0004972
<http://purl.obolibrary.org/obo/GO_0004972> rdf:type owl:Class .

### http://purl.obolibrary.org/obo/MP_0002229
<http://purl.obolibrary.org/obo/MP_0002229> rdf:type owl:Class .

### http://purl.obolibrary.org/obo/CHEBI_39124
<http://purl.obolibrary.org/obo/CHEBI_39124> rdf:type owl:Class .

### http://purl.obolibrary.org/obo/GO_0006816
<http://purl.obolibrary.org/obo/GO_0006816> rdf:type owl:Class .

### http://purl.obolibrary.org/obo/PR_000004716
<http://purl.obolibrary.org/obo/PR_000004716> rdf:type owl:Class .

### http://purl.obolibrary.org/obo/GO_0010467
<http://purl.obolibrary.org/obo/GO_0010467> rdf:type owl:Class .

### http://purl.obolibrary.org/obo/GO_0046903
<http://purl.obolibrary.org/obo/GO_0046903> rdf:type owl:Class .

### http://purl.obolibrary.org/obo/GO_0008219
<http://purl.obolibrary.org/obo/GO_0008219> rdf:type owl:Class .

### http://purl.obolibrary.org/obo/CL_0000129
<http://purl.obolibrary.org/obo/CL_0000129> rdf:type owl:Class .

### http://purl.obolibrary.org/obo/MP_0001847
<http://purl.obolibrary.org/obo/MP_0001847> rdf:type owl:Class .

### http://purl.obolibrary.org/obo/CL_0000127
<http://purl.obolibrary.org/obo/CL_0000127> rdf:type owl:Class .

### http://purl.obolibrary.org/obo/GO_0007612
<http://purl.obolibrary.org/obo/GO_0007612> rdf:type owl:Class .

### http://purl.obolibrary.org/obo/GO_0007613
<http://purl.obolibrary.org/obo/GO_0007613> rdf:type owl:Class .



#################################################################
# Individuals
#################################################################

### http://www.co-ode.org/ontologies/ont.owl#NMDA%20selective%20glutamate%20receptor%20complex
<http://www.co-ode.org/ontologies/ont.owl#NMDA%20selective%20glutamate%20receptor%20complex> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/GO_0017146> ;
<http://purl.obolibrary.org/obo/RO_0002331> :NMDA%20glutamate%20receptor%20activity ;
<http://purl.obolibrary.org/obo/RO_0002327> :NMDA%20glutamate%20receptor%20activity ;
<http://purl.obolibrary.org/obo/RO_0002353> :NMDA%20glutamate%20receptor%20activity ;
<http://purl.obolibrary.org/obo/RO_0002428> :NMDA%20glutamate%20receptor%20activity .

### http://www.co-ode.org/ontologies/ont.owl#NMDA%20glutamate%20receptor%20activity
<http://www.co-ode.org/ontologies/ont.owl#NMDA%20glutamate%20receptor%20activity> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/GO_0004972> ;
<http://purl.obolibrary.org/obo/RO_0002410> :calcium%20ion%20transport .

### http://www.co-ode.org/ontologies/ont.owl#calcium%20ion
<http://www.co-ode.org/ontologies/ont.owl#calcium%20ion> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/CHEBI_39124> ;
<http://purl.obolibrary.org/obo/RO_0002331> :calcium%20ion%20transport ;
<http://purl.obolibrary.org/obo/RO_0002327> :calcium%20ion%20transport ;
<http://purl.obolibrary.org/obo/RO_0002353> :calcium%20ion%20transport ;
<http://purl.obolibrary.org/obo/RO_0002428> :calcium%20ion%20transport .

### http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport
<http://www.co-ode.org/ontologies/ont.owl#calcium%20ion%20transport> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/GO_0006816> ;
<http://purl.obolibrary.org/obo/RO_0002410> :gene%20expression ;
<http://purl.obolibrary.org/obo/RO_0002410> :secretion .

### http://www.co-ode.org/ontologies/ont.owl#brain-derived%20neurotrophic%20factor
<http://www.co-ode.org/ontologies/ont.owl#brain-derived%20neurotrophic%20factor> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/PR_000004716> ;
<http://purl.obolibrary.org/obo/RO_0002331> :gene%20expression ;
<http://purl.obolibrary.org/obo/RO_0002327> :gene%20expression ;
<http://purl.obolibrary.org/obo/RO_0002353> :gene%20expression ;
<http://purl.obolibrary.org/obo/RO_0002428> :gene%20expression .

### http://www.co-ode.org/ontologies/ont.owl#gene%20expression
<http://www.co-ode.org/ontologies/ont.owl#gene%20expression> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/GO_0010467> ;
<http://purl.obolibrary.org/obo/RO_0002410> :cell%20death .

### http://www.co-ode.org/ontologies/ont.owl#brain-derived%20neurotrophic%20factor
<http://www.co-ode.org/ontologies/ont.owl#brain-derived%20neurotrophic%20factor> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/PR_000004716> ;
<http://purl.obolibrary.org/obo/RO_0002331> :secretion ;
<http://purl.obolibrary.org/obo/RO_0002327> :secretion ;
<http://purl.obolibrary.org/obo/RO_0002353> :secretion ;
<http://purl.obolibrary.org/obo/RO_0002428> :secretion .

### http://www.co-ode.org/ontologies/ont.owl#secretion
<http://www.co-ode.org/ontologies/ont.owl#secretion> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/GO_0046903> ;
<http://purl.obolibrary.org/obo/RO_0002410> :cell%20death .

### http://www.co-ode.org/ontologies/ont.owl#cell%20death
<http://www.co-ode.org/ontologies/ont.owl#cell%20death> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/GO_0008219> ;
<http://purl.obolibrary.org/obo/RO_0019000> :brain%20inflammation ;
<http://purl.obolibrary.org/obo/RO_0019000> :brain%20inflammation .

### http://www.co-ode.org/ontologies/ont.owl#microglial%20cell
<http://www.co-ode.org/ontologies/ont.owl#microglial%20cell> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/CL_0000129> ;
<http://purl.obolibrary.org/obo/RO_0002610> :brain%20inflammation ;
<http://purl.obolibrary.org/obo/RO_0000053> :brain%20inflammation .

### http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation
<http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/MP_0001847> ;
<http://purl.obolibrary.org/obo/RO_0003303> :neurodegeneration ;
<http://purl.obolibrary.org/obo/RO_0002610> :neurodegeneration .

### http://www.co-ode.org/ontologies/ont.owl#astrocyte
<http://www.co-ode.org/ontologies/ont.owl#astrocyte> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/CL_0000127> ;
<http://purl.obolibrary.org/obo/RO_0002610> :brain%20inflammation ;
<http://purl.obolibrary.org/obo/RO_0000053> :brain%20inflammation .

### http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation
<http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/MP_0001847> ;
<http://purl.obolibrary.org/obo/RO_0003303> :neurodegeneration ;
<http://purl.obolibrary.org/obo/RO_0002610> :neurodegeneration .

### http://www.co-ode.org/ontologies/ont.owl#neurodegeneration
<http://www.co-ode.org/ontologies/ont.owl#neurodegeneration> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/MP_0002229> ;
<http://purl.obolibrary.org/obo/RO_0003303> :brain%20inflammation ;
<http://purl.obolibrary.org/obo/RO_0002610> :brain%20inflammation ;
<http://purl.obolibrary.org/obo/RO_0003303> :brain%20inflammation ;
<http://purl.obolibrary.org/obo/RO_0002610> :brain%20inflammation .

### http://www.co-ode.org/ontologies/ont.owl#learning
<http://www.co-ode.org/ontologies/ont.owl#learning> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/GO_0007612> .

### http://www.co-ode.org/ontologies/ont.owl#memory
<http://www.co-ode.org/ontologies/ont.owl#memory> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/GO_0007613> .

### http://www.co-ode.org/ontologies/ont.owl#microglial%20cell
<http://www.co-ode.org/ontologies/ont.owl#microglial%20cell> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/CL_0000129> ;
<http://purl.obolibrary.org/obo/RO_0002610> :brain%20inflammation ;
<http://purl.obolibrary.org/obo/RO_0000053> :brain%20inflammation .

### http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation
<http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/MP_0001847> ;
<http://purl.obolibrary.org/obo/RO_0003303> :neurodegeneration ;
<http://purl.obolibrary.org/obo/RO_0002610> :neurodegeneration .

### http://www.co-ode.org/ontologies/ont.owl#astrocyte
<http://www.co-ode.org/ontologies/ont.owl#astrocyte> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/CL_0000127> ;
<http://purl.obolibrary.org/obo/RO_0002610> :brain%20inflammation ;
<http://purl.obolibrary.org/obo/RO_0000053> :brain%20inflammation .

### http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation
<http://www.co-ode.org/ontologies/ont.owl#brain%20inflammation> rdf:type owl:NamedIndividual ,
<http://purl.obolibrary.org/obo/MP_0001847> ;
<http://purl.obolibrary.org/obo/RO_0003303> :neurodegeneration ;
<http://purl.obolibrary.org/obo/RO_0002610> :neurodegeneration .



#################################################################
# Object Statements
#################################################################

<http://purl.obolibrary.org/obo/RO_0002331> rdf:type owl:ObjectProperty .
<http://purl.obolibrary.org/obo/RO_0002327> rdf:type owl:ObjectProperty .
<http://purl.obolibrary.org/obo/RO_0002353> rdf:type owl:ObjectProperty .
<http://purl.obolibrary.org/obo/RO_0002428> rdf:type owl:ObjectProperty .
<http://purl.obolibrary.org/obo/RO_0002410> rdf:type owl:ObjectProperty .
<http://purl.obolibrary.org/obo/RO_0003303> rdf:type owl:ObjectProperty .
<http://purl.obolibrary.org/obo/RO_0002610> rdf:type owl:ObjectProperty .
<http://purl.obolibrary.org/obo/RO_0019000> rdf:type owl:ObjectProperty .
<http://purl.obolibrary.org/obo/RO_0000053> rdf:type owl:ObjectProperty .
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