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53 changes: 31 additions & 22 deletions src/single_cell/AbstractActionPotentialMethod.cpp
Original file line number Diff line number Diff line change
Expand Up @@ -358,15 +358,34 @@ OdeSolution AbstractActionPotentialMethod::PerformAnalysisOfTwoPaces(
// Get voltage properties
const unsigned voltage_index = pModel->GetSystemInformation()->GetStateVariableIndex("membrane_voltage");
std::vector<double> voltages = solution.GetVariableAtIndex(voltage_index);
CellProperties voltage_properties(voltages, solution.rGetTimes(),
mActionPotentialThreshold);
std::vector<double> times = solution.rGetTimes();


std::vector<double> apd90s;
std::vector<double> peak_voltages;
// See if we can get back some action potential duration(s).
try
{
apd90s = voltage_properties.GetAllActionPotentialDurations(90);

// split into num_paces_to_analyze paces for analysis
std::vector<CellProperties> voltage_properties;
for (unsigned pace = 0; pace < num_paces_to_analyze; pace++)
{
// find the start and end of the pace
const size_t pace_start_index = static_cast<size_t>(std::floor(pace * s1_period / printingTimeStep));
const size_t pace_end_index = static_cast<size_t>(std::floor((pace + 1) * s1_period / printingTimeStep));

// extract times and voltages
std::vector<double> pace_times(std::begin(times) + pace_start_index, std::begin(times) + pace_end_index);
std::vector<double> pace_voltages(std::begin(voltages) + pace_start_index, std::begin(voltages) + pace_end_index);

// contruct CellProperties and save for later
CellProperties voltage_properties_for_pace(pace_voltages, pace_times, mActionPotentialThreshold);
voltage_properties.push_back(voltage_properties_for_pace);
auto apd90s_for_pace = voltage_properties_for_pace.GetAllActionPotentialDurations(90);
apd90s.insert(std::end(apd90s), std::begin(apd90s_for_pace), std::end(apd90s_for_pace));
}

if (!mSuppressOutput)
{
std::cout << "Last " << apd90s.size()
Expand All @@ -378,25 +397,15 @@ OdeSolution AbstractActionPotentialMethod::PerformAnalysisOfTwoPaces(
std::cout << std::endl; //<< std::flush;
}

if (apd90s.size() >= 2u && fabs(apd90s[0] - apd90s[1]) > alternans_threshold)
{
// We suspect alternans, and analyse the first of the two APs
rApd90 = voltage_properties.GetAllActionPotentialDurations(90)[0];
rApd50 = voltage_properties.GetAllActionPotentialDurations(50)[0];
rUpstroke = voltage_properties.GetMaxUpstrokeVelocities()[0];
peak_voltages = voltage_properties.GetPeakPotentials();
rPeak = peak_voltages[0];
rPeakTime = voltage_properties.GetTimesAtPeakPotentials()[0];
}
else
{
// Return the last as it is more likely to be the steady state one.
rApd90 = voltage_properties.GetLastActionPotentialDuration(90);
rApd50 = voltage_properties.GetLastActionPotentialDuration(50);
rUpstroke = voltage_properties.GetLastCompleteMaxUpstrokeVelocity();
rPeak = voltage_properties.GetLastCompletePeakPotential();
rPeakTime = voltage_properties.GetTimeAtLastCompletePeakPotential();
}
// if we suspect alternans, analyse the first of the two APs, otherwise the
// second
const unsigned analysis_pace_index = (apd90s.size() >= 2u && fabs(apd90s[0] - apd90s[1]) > alternans_threshold) ? 0u : 1u;
rApd90 = voltage_properties[analysis_pace_index].GetLastActionPotentialDuration(90);
rApd50 = voltage_properties[analysis_pace_index].GetLastActionPotentialDuration(50);
rUpstroke = voltage_properties[analysis_pace_index].GetLastCompleteMaxUpstrokeVelocity();
rPeak = voltage_properties[analysis_pace_index].GetLastCompletePeakPotential();
rPeakTime = voltage_properties[analysis_pace_index].GetTimeAtLastCompletePeakPotential();

// It makes sense to return the peak voltage time relative to start of
// stimulus application.
boost::shared_ptr<RegularStimulus> p_reg_stim = boost::static_pointer_cast<RegularStimulus>(
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