diff --git a/scripts/run_benchmark/run_full_local.sh b/scripts/run_benchmark/run_full_local.sh
index 20e434b3..84a60b60 100755
--- a/scripts/run_benchmark/run_full_local.sh
+++ b/scripts/run_benchmark/run_full_local.sh
@@ -26,7 +26,7 @@ input_states: resources/datasets/**/state.yaml
 rename_keys: 'input_dataset:output_dataset;input_solution:output_solution'
 output_state: "state.yaml"
 publish_dir: "$publish_dir"
-settings: '{"methods_exclude": ["uce", "scgpt_finetuned"]}'
+settings: '{"methods_exclude": ["uce", "scgpt_finetuned", "cellplm"]}'
 HERE
 
 # run the benchmark
diff --git a/scripts/run_benchmark/run_test_local.sh b/scripts/run_benchmark/run_test_local.sh
index 85e39583..3d9de958 100755
--- a/scripts/run_benchmark/run_test_local.sh
+++ b/scripts/run_benchmark/run_test_local.sh
@@ -21,7 +21,7 @@ input_states: resources_test/task_batch_integration/**/state.yaml
 rename_keys: 'input_dataset:output_dataset;input_solution:output_solution'
 output_state: "state.yaml"
 publish_dir: "$publish_dir"
-settings: '{"methods_exclude": ["uce", "scgpt_finetuned"]}'
+settings: '{"methods_exclude": ["uce", "scgpt_finetuned", "cellplm]}'
 HERE
 
 nextflow run . \
diff --git a/src/methods/cellplm/config.vsh.yaml b/src/methods/cellplm/config.vsh.yaml
new file mode 100755
index 00000000..df8b9e71
--- /dev/null
+++ b/src/methods/cellplm/config.vsh.yaml
@@ -0,0 +1,51 @@
+__merge__: ../../api/base_method.yaml
+
+name: cellplm
+
+label: CellPLM
+
+summary: "A foundation model pre-trained with cells as tokens."
+
+description: |
+  CellPLM is a pre-trained language model specifically designed for single-cell analysis that leverages the principles of natural language processing (NLP) to understand and process single-cell gene expression data.
+references:
+  doi:
+    - 10.1101/2023.10.03.560734
+links:
+  documentation: https://github.com/OmicsML/CellPLM/tree/main/tutorials
+  repository: https://github.com/OmicsML/CellPLM
+
+info:
+  method_types: [embedding]
+  preferred_normalization: counts
+
+arguments:
+  - name: --model_name
+    type: string
+    description: String giving the CellPLM model to use
+    choices: ["20231027_85M", "20230926_85M"]
+    default: "20231027_85M"
+  - name: --model
+    type: file
+    description: Path to the directory containing CellPLM model files or a .zip/.tar.gz archive
+    required: true
+
+resources:
+  - type: python_script
+    path: script.py
+  - path: /src/utils/read_anndata_partial.py
+  - path: /src/utils/exit_codes.py
+
+engines:
+  - type: docker
+    image: openproblems/base_pytorch_nvidia:1.0.0
+    setup:
+      - type: python
+        pypi:
+          - cellplm
+
+runners:
+  - type: executable
+  - type: nextflow
+    directives:
+      label: [midtime, midmem, midcpu, gpu]
diff --git a/src/methods/cellplm/script.py b/src/methods/cellplm/script.py
new file mode 100644
index 00000000..6e6a20c8
--- /dev/null
+++ b/src/methods/cellplm/script.py
@@ -0,0 +1,104 @@
+import os
+import sys
+import tarfile
+import tempfile
+import zipfile
+
+import anndata as ad
+import torch
+from CellPLM.pipeline.cell_embedding import CellEmbeddingPipeline
+from CellPLM.utils import set_seed
+
+## VIASH START
+# Note: this section is auto-generated by viash at runtime. To edit it, make changes
+# in config.vsh.yaml and then run `viash config inject config.vsh.yaml`.
+
+par = {
+    "input": "resources_test/.../input.h5ad",
+    "output": "output.h5ad",
+    "model": "20231027_85M",
+}
+meta = {"name": "cellplm"}
+## VIASH END
+
+sys.path.append(meta["resources_dir"])
+from exit_codes import exit_non_applicable
+from read_anndata_partial import read_anndata
+
+set_seed(24)
+device = "cuda" if torch.cuda.is_available() else "cpu"
+if device == "cpu":
+    import warnings
+
+    warnings.warn("Loading CellPLM models requires a GPU, this run will fail")
+
+print("\n>>> Reading input files...", flush=True)
+print(f"Input H5AD file: '{par['input']}'", flush=True)
+adata = read_anndata(par["input"], X="layers/counts", obs="obs", var="var", uns="uns")
+
+if adata.uns["dataset_organism"] != "homo_sapiens":
+    exit_non_applicable(
+        f"CellPLM can only be used with human data "
+        f'(dataset_organism == "{adata.uns["dataset_organism"]}")'
+    )
+
+print(adata, flush=True)
+
+print("\n>>> Getting model files...", flush=True)
+# Available from https://www.dropbox.com/scl/fo/i5rmxgtqzg7iykt2e9uqm/h/ckpt?dl=0&subfolder_nav_tracking=1
+if os.path.isdir(par["model"]):
+    model_temp = None
+    model_dir = par["model"]
+else:
+    model_temp = tempfile.TemporaryDirectory()
+    model_dir = model_temp.name
+
+    if zipfile.is_zipfile(par["model"]):
+        print("Extracting CellPLM models from .zip...", flush=True)
+        with zipfile.ZipFile(par["model"], "r") as zip_file:
+            zip_file.extractall(model_dir)
+    elif tarfile.is_tarfile(par["model"]) and par["model"].endswith(".tar.gz"):
+        print("Extracting CellPLM models from .tar.gz...", flush=True)
+        with tarfile.open(par["model"], "r:gz") as tar_file:
+            tar_file.extractall(model_dir)
+            model_dir = os.path.join(model_dir, os.listdir(model_dir)[0])
+    else:
+        raise ValueError(
+            "The 'model' argument should be a directory a .zip file or a .tar.gz file"
+        )
+
+print(f"Model directory: '{model_dir}'", flush=True)
+
+print("\n>>> Creating embedding model pipeline...", flush=True)
+pipeline = CellEmbeddingPipeline(
+    pretrain_prefix=par["model_name"], pretrain_directory=model_dir
+)
+
+print("\n>>> Embedding data...", flush=True)
+embedding = pipeline.predict(adata, device=device)
+embedding = embedding.cpu().numpy()
+
+print("\n>>> Storing output...", flush=True)
+output = ad.AnnData(
+    obs=adata.obs[[]],
+    var=adata.var[[]],
+    obsm={
+        "X_emb": embedding,
+    },
+    uns={
+        "dataset_id": adata.uns["dataset_id"],
+        "normalization_id": adata.uns["normalization_id"],
+        "method_id": meta["name"],
+    },
+)
+print(output)
+
+print("\n>>> Writing output to file...", flush=True)
+print(f"Output H5AD file: '{par['output']}'", flush=True)
+output.write_h5ad(par["output"], compression="gzip")
+
+if model_temp is not None:
+    print("\n>>> Cleaning up temporary directories...", flush=True)
+    model_temp.cleanup()
+
+print("\n>>> Done!", flush=True)
diff --git a/src/workflows/run_benchmark/config.vsh.yaml b/src/workflows/run_benchmark/config.vsh.yaml
index 5cd9b339..c53035fd 100644
--- a/src/workflows/run_benchmark/config.vsh.yaml
+++ b/src/workflows/run_benchmark/config.vsh.yaml
@@ -91,6 +91,7 @@ dependencies:
   - name: methods/batchelor_fastmnn
   - name: methods/batchelor_mnn_correct
   - name: methods/bbknn
+  - name: methods/cellplm
   - name: methods/combat
   - name: methods/geneformer
   - name: methods/harmony
diff --git a/src/workflows/run_benchmark/main.nf b/src/workflows/run_benchmark/main.nf
index e4e1ad32..5c34f1c0 100644
--- a/src/workflows/run_benchmark/main.nf
+++ b/src/workflows/run_benchmark/main.nf
@@ -19,6 +19,9 @@ methods = [
   batchelor_fastmnn,
   batchelor_mnn_correct,
   bbknn,
+  cellplm.run(
+    args: [model: file("s3://openproblems-work/cache/cellplm-ckpt.zip")]
+  ),
   combat,
   geneformer,
   harmony,