book.bib

@article{RN2,
   author = {Baslan, T. and Kendall, J. and Rodgers, L. and Cox, H. and Riggs, M. and Stepansky, A. and Troge, J. and Ravi, K. and Esposito, D. and Lakshmi, B. and Wigler, M. and Navin, N. and Hicks, J.},
   title = {Genome-wide copy number analysis of single cells},
   journal = {Nat Protoc},
   volume = {7},
   number = {6},
   pages = {1024-41},
   ISSN = {1750-2799 (Electronic)
1750-2799 (Linking)},
   DOI = {10.1038/nprot.2012.039},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/22555242},
   year = {2012},
   type = {Journal Article}
}

@article{RN3,
   author = {Davis, A. and Gao, R. and Navin, N.},
   title = {Tumor evolution: Linear, branching, neutral or punctuated?},
   journal = {Biochim Biophys Acta Rev Cancer},
   volume = {1867},
   number = {2},
   pages = {151-161},
   ISSN = {0304-419X (Print)
0304-419X (Linking)},
   DOI = {10.1016/j.bbcan.2017.01.003},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/28110020},
   year = {2017},
   type = {Journal Article}
}

@article{RN4,
   author = {Gao, R. and Davis, A. and McDonald, T. O. and Sei, E. and Shi, X. and Wang, Y. and Tsai, P. C. and Casasent, A. and Waters, J. and Zhang, H. and Meric-Bernstam, F. and Michor, F. and Navin, N. E.},
   title = {Punctuated copy number evolution and clonal stasis in triple-negative breast cancer},
   journal = {Nat Genet},
   volume = {48},
   number = {10},
   pages = {1119-30},
   ISSN = {1546-1718 (Electronic)
1061-4036 (Linking)},
   DOI = {10.1038/ng.3641},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/27526321},
   year = {2016},
   type = {Journal Article}
}

@article{RN13,
   author = {Navin, N. and Kendall, J. and Troge, J. and Andrews, P. and Rodgers, L. and McIndoo, J. and Cook, K. and Stepansky, A. and Levy, D. and Esposito, D. and Muthuswamy, L. and Krasnitz, A. and McCombie, W. R. and Hicks, J. and Wigler, M.},
   title = {Tumour evolution inferred by single-cell sequencing},
   journal = {Nature},
   volume = {472},
   number = {7341},
   pages = {90-4},
   note = {Navin, Nicholas
Kendall, Jude
Troge, Jennifer
Andrews, Peter
Rodgers, Linda
McIndoo, Jeanne
Cook, Kerry
Stepansky, Asya
Levy, Dan
Esposito, Diane
Muthuswamy, Lakshmi
Krasnitz, Alex
McCombie, W Richard
Hicks, James
Wigler, Michael
eng
T32 CA009176/CA/NCI NIH HHS/
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
England
2011/03/15
Nature. 2011 Apr 7;472(7341):90-4. doi: 10.1038/nature09807. Epub 2011 Mar 13.},
   abstract = {Genomic analysis provides insights into the role of copy number variation in disease, but most methods are not designed to resolve mixed populations of cells. In tumours, where genetic heterogeneity is common, very important information may be lost that would be useful for reconstructing evolutionary history. Here we show that with flow-sorted nuclei, whole genome amplification and next generation sequencing we can accurately quantify genomic copy number within an individual nucleus. We apply single-nucleus sequencing to investigate tumour population structure and evolution in two human breast cancer cases. Analysis of 100 single cells from a polygenomic tumour revealed three distinct clonal subpopulations that probably represent sequential clonal expansions. Additional analysis of 100 single cells from a monogenomic primary tumour and its liver metastasis indicated that a single clonal expansion formed the primary tumour and seeded the metastasis. In both primary tumours, we also identified an unexpectedly abundant subpopulation of genetically diverse 'pseudodiploid' cells that do not travel to the metastatic site. In contrast to gradual models of tumour progression, our data indicate that tumours grow by punctuated clonal expansions with few persistent intermediates.},
   keywords = {Breast Neoplasms/diagnosis/*genetics/*pathology
Carcinoma, Ductal, Breast/diagnosis/genetics/pathology
Chromosome Breakpoints
Clone Cells/cytology
Diploidy
Disease Progression
*Evolution, Molecular
Female
Flow Cytometry
Genetic Heterogeneity
Genome, Human/genetics
Genomics
Humans
Liver Neoplasms/genetics/secondary
Loss of Heterozygosity
Sequence Analysis, DNA/*methods
Single-Cell Analysis/*methods},
   ISSN = {1476-4687 (Electronic)
0028-0836 (Linking)},
   DOI = {10.1038/nature09807},
   url = {https://www.ncbi.nlm.nih.gov/pubmed/21399628},
   year = {2011},
   type = {Journal Article}
}