This repository contains the code and analysis instructions for the B7-H3 project.
Dual Functions of B7-H3–MAPK Signaling Orchestrate Tumor Immunosuppression by Regulating the Plasticity of MDSCs and Fibroblasts
| Analysis Part | Purpose | Link |
|---|---|---|
| PbPPCd276 analysis | Single-cell RNA sequencing (scRNA-seq) analysis of prostate tumors from PB-Cre;PtenL/L;Trp53L/L (PbPP) and PB-Cre;PtenL/L;Trp53L/L;Cd276L/L (PbPPCd276) genetically engineered mouse models (GEMMs). | Code |
| Treatment analysis | Evaluation of therapeutic efficacy by combining B7-H3 monoclonal antibody (mAb) treatment with MEK inhibitor therapy. | Code |
| Human data analysis | Analysis of publicly available human single-cell RNA-seq datasets from the Gene Expression Omnibus (GEO), accession GSE274229. | Code |
| Other functions | Supporting scripts for analyses, including cell type composition comparison and marker gene heatmap visualization. | Cell Type Composition Comparison, Marker Gene Heatmap |
- Each analysis step is documented in the corresponding code link.