diff --git a/README.md b/README.md
index 243434f..c24f1d2 100644
--- a/README.md
+++ b/README.md
@@ -83,6 +83,8 @@ If you want to use platform-specific default features, use the `ct2rs-platform`
 
 - `whisper`: Enables [Whisper](https://huggingface.co/docs/transformers/model_doc/whisper) model support
 - `hub`: Enables [HuggingFace Hub](https://huggingface.co/docs/hub) integration
+- `system`: Skip compiling CTranslate2 and use the system's pre-installed shared library instead (requires setting the
+  appropriate environment variables to locate the CTranslate2 shared library)
 
 ### Platform Specific Features
 
diff --git a/ct2rs-platform/Cargo.toml b/ct2rs-platform/Cargo.toml
index 45c102b..73581f4 100644
--- a/ct2rs-platform/Cargo.toml
+++ b/ct2rs-platform/Cargo.toml
@@ -44,6 +44,7 @@ features = ["openmp-runtime-comp", "openblas", "ruy"]
 default = ["all-tokenizers", "cuda-small-binary"]
 whisper = ["ct2rs/whisper"]
 hub = ["ct2rs/hub"]
+system = ["ct2rs/system"]
 
 # Features to select backends.
 mkl = ["ct2rs/mkl"]
diff --git a/ct2rs/Cargo.toml b/ct2rs/Cargo.toml
index 4e752f0..8d5c5e4 100644
--- a/ct2rs/Cargo.toml
+++ b/ct2rs/Cargo.toml
@@ -75,6 +75,7 @@ whisper = [
     "all-tokenizers",
 ]
 hub = ["dep:hf-hub"]
+system = ["intel-onemkl-prebuild?/system", "openblas-src?/system"]
 
 # Features to select backends.
 cuda = []
diff --git a/ct2rs/build.rs b/ct2rs/build.rs
index d7eb42b..a1d8fec 100644
--- a/ct2rs/build.rs
+++ b/ct2rs/build.rs
@@ -31,15 +31,7 @@ enum Os {
     Unknown,
 }
 
-fn main() {
-    println!("cargo:rerun-if-changed=build.rs");
-    println!("cargo:rerun-if-changed=src/sys");
-    println!("cargo:rerun-if-changed=include");
-    println!("cargo:rerun-if-changed=CTranslate2");
-    add_search_paths("LIBRARY_PATH");
-    println!("cargo:rerun-if-env-changed=CMAKE_INCLUDE_PATH");
-    add_search_paths("CMAKE_LIBRARY_PATH");
-
+fn build_ctranslate2() {
     let mut cmake = Config::new("CTranslate2");
     match env::var("CMAKE_PARALLEL") {
         Ok(job_n) => {
@@ -198,6 +190,101 @@ fn main() {
 
     let ctranslate2 = cmake.build();
     link_libraries(ctranslate2.join("build"));
+}
+
+fn link_system_libraries() {
+    println!("cargo:rustc-link-lib=ctranslate2");
+    if cfg!(target_arch = "x86_64") {
+        println!("cargo:rustc-link-lib=cpu_features");
+    }
+    if cfg!(feature = "cuda") {
+        println!("cargo:rustc-link-lib=static=cudart_static");
+    }
+    if cfg!(feature = "cudnn") {
+        println!("cargo:rustc-link-lib=cudnn");
+    }
+    if cfg!(all(
+        not(feature = "cuda-dynamic-loading"),
+        not(target_os = "macos")
+    )) {
+        if cfg!(target_os = "windows") {
+            println!("cargo:rustc-link-lib=static=cublas");
+            println!("cargo:rustc-link-lib=static=cublasLt");
+        } else {
+            println!("cargo:rustc-link-lib=static=cublas_static");
+            println!("cargo:rustc-link-lib=static=cublasLt_static");
+            println!("cargo:rustc-link-lib=static=culibos");
+        }
+    }
+    if cfg!(feature = "accelerate") {
+        println!("cargo:rustc-link-lib=framework=Accelerate");
+    }
+    if cfg!(feature = "ruy") {
+        println!("cargo:rustc-link-lib=cpuinfo");
+        println!("cargo:rustc-link-lib=clog");
+        println!("cargo:rustc-link-lib=ruy_allocator");
+        println!("cargo:rustc-link-lib=ruy_apply_multiplier");
+        println!("cargo:rustc-link-lib=ruy_block_map");
+        println!("cargo:rustc-link-lib=ruy_blocking_counter");
+        println!("cargo:rustc-link-lib=ruy_context");
+        println!("cargo:rustc-link-lib=ruy_context_get_ctx");
+        println!("cargo:rustc-link-lib=ruy_cpuinfo");
+        println!("cargo:rustc-link-lib=ruy_ctx");
+        println!("cargo:rustc-link-lib=ruy_denormal");
+        println!("cargo:rustc-link-lib=ruy_frontend");
+        println!("cargo:rustc-link-lib=ruy_prepacked_cache");
+        println!("cargo:rustc-link-lib=ruy_prepare_packed_matrices");
+        println!("cargo:rustc-link-lib=ruy_profiler_instrumentation");
+        println!("cargo:rustc-link-lib=ruy_system_aligned_alloc");
+        println!("cargo:rustc-link-lib=ruy_thread_pool");
+        println!("cargo:rustc-link-lib=ruy_trmul");
+        println!("cargo:rustc-link-lib=ruy_tune");
+        println!("cargo:rustc-link-lib=ruy_wait");
+        if cfg!(any(target_arch = "arm", target_arch = "aarch64")) {
+            println!("cargo:rustc-link-lib=ruy_kernel_arm");
+            println!("cargo:rustc-link-lib=ruy_pack_arm");
+        }
+        if cfg!(target_feature = "avx") {
+            println!("cargo:rustc-link-lib=ruy_have_built_path_for_avx");
+            println!("cargo:rustc-link-lib=ruy_kernel_avx");
+            println!("cargo:rustc-link-lib=ruy_pack_avx");
+        }
+        if cfg!(target_feature = "avx2") {
+            println!("cargo:rustc-link-lib=ruy_have_built_path_for_avx2_fma");
+            println!("cargo:rustc-link-lib=ruy_kernel_avx2_fma");
+            println!("cargo:rustc-link-lib=ruy_pack_avx2_fma");
+        }
+        if cfg!(target_feature = "avx512f") {
+            println!("cargo:rustc-link-lib=ruy_have_built_path_for_avx512");
+            println!("cargo:rustc-link-lib=ruy_kernel_avx512");
+            println!("cargo:rustc-link-lib=ruy_pack_avx512");
+        }
+    }
+    if cfg!(feature = "dnnl") {
+        println!("cargo:rustc-link-lib=dnnl");
+    }
+    if cfg!(feature = "openmp-runtime-comp") {
+        println!("cargo:rustc-link-lib=gomp");
+    }
+    if cfg!(feature = "openmp-runtime-intel") {
+        println!("cargo:rustc-link-lib=iomp5");
+    }
+}
+
+fn main() {
+    println!("cargo:rerun-if-changed=build.rs");
+    println!("cargo:rerun-if-changed=src/sys");
+    println!("cargo:rerun-if-changed=include");
+    println!("cargo:rerun-if-changed=CTranslate2");
+    add_search_paths("LIBRARY_PATH");
+    println!("cargo:rerun-if-env-changed=CMAKE_INCLUDE_PATH");
+    add_search_paths("CMAKE_LIBRARY_PATH");
+
+    if cfg!(feature = "system") {
+        link_system_libraries();
+    } else {
+        build_ctranslate2()
+    }
 
     cxx_build::bridges([
         "src/sys/types.rs",