Multiple dose within for 1 sampling ID period

[jeslo328]

Hi
I would like to ask for guidance on how to calculate the pk parameters such as Cmax, Cmin,....AUC... for let’s say i have sampling for a ID from 0 - 24 hours but i gave does at perhaps at 0,2,8 hours. My pk parameters of interest are for 0-24 hours. How do i set the data in the PKNCA dose.

Help pls
Jesmin

[billdenney]

For multiple doses in an interval, you set the data for the dose just like any other dosing dataset (give the dose amount, time, and groupings to the PKNCAdose() function as described in https://humanpred.github.io/pknca/articles/v01-introduction-and-usage.html#quick-start), and PKNCA will automatically sum the doses for you if there is more than one dose in an interval.

[jeslo328]

Such i will have 3 rows of dose for an ID if he/she received 3 doses in 24 hours ?

[billdenney]

That's right.