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![diffUSE Project logo](/assets/images/diffuse_logo_banner.jpg){:style="max-height:300px; display: block; margin-left: auto; margin-right: auto;"}
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## Unlocking Protein Dynamics Through X-Ray Crystallography
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Structural biology has long been a key enabler for drug discovery, and for understanding protein function. As a field, structural biology has come a long way towards our understanding of static protein structures. But, proteins are dynamic and their functions are critically linked to fluctuations in state and motion. Our ability to measure these protein motions experimentally has been limited. To unlock the next frontier of advancements, we need more new method advancements, more experimental data, and ways to model and encode the dynamics of proteins.
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Structural biology has long been a key enabler for drug discovery, and for understanding protein function. As a field, structural biology has come a long way towards our understanding of static protein structures. But, proteins are dynamic and their functions are critically linked to fluctuations in state and motion. Our ability to measure these protein motions experimentally has been limited. To unlock the next frontier of advancements, we need more new method advancements, more experimental data, and better ways to model and encode the dynamics of proteins.
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<!-- ![diffuse scattering slice](/assets/images/20250624_mapslice.png){:style="max-height:220px; display: inline; margin-left: auto; margin-right: auto;"} -->
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![diffuse scattering signals](/assets/images/diffuse_signals.png){:style="max-height:300px; display: block; margin-left: auto; margin-right: auto;"}
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The Diffuse Project is dedicated to advancing our understanding of protein motion through the use of diffuse scattering: a signal measured by X-ray crystallography, which is currently ignored, but could unlock our ability to measure protein dynamics. We are also focused on building the infrastructure for learning and representing the rich information from this data.
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The Diffuse Project is dedicated to advancing our understanding of protein motion through the use of diffuse scattering: a signal measured by X-ray crystallography, which is currently ignored, but could unlock our ability to measure protein dynamics.
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The project aims to build the infrastructure for learning and representing the rich information from this data.
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The Diffuse Project was co-developed with funders and a team of software developers, beamline scientists, structural biologists (experimental and computational), and modelers. The team includes both dedicated staff and institutional researchers to enable fast-paced infrastructure-building and specialized basic research. We will tackle the problem at a systems level by jointly iterating on data collection, sample preparation, hardware, software development, modeling algorithm development, and encoding strategies.
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