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Nitin Gupta
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about page styling
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permalink: /about/
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title: "About"
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title: "About The Diffuse Project"
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**An ambitious push to make protein motion routine**
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**An ambitious push to make protein motion routine**<br>
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Structural biology is ready for its next leap. The Diffuse Project sets out to turn the faint “diffuse” background in X-ray diffraction images into everyday maps of how proteins breathe and bend—information that static crystal structures and even AlphaFold predictions leave behind.
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**Why now?**
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**Why now?**<br>
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Static structures have plateaued. AlphaFold and traditional crystallography capture only a single snapshot; the diffuse signal around Bragg peaks holds the hidden information needed to model motion. With room-temperature collection methods improving and GPUs putting heavy computation within reach, the field finally has the tools to make that signal mainstream.
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