phenoage0 calculation #7
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Hello, Thanks for creating this very useful package! I have a question about calculation of the phenotypic age based on the original coefficients. This is the formula I saw in the original paper for calculating phenotypic age: However, I saw an additional step in your calculations for calculating m_orig: Could you please explain why there is an additional step? Thanks again! |
Replies: 1 comment
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Hello, As you can see from Levine 2018 (supplementary methods), the formula you attached is just a part of the equation. In order to fully solve the equation to get PhenoAge, you need to compute a mortality prediction score (CDF(120,x)) first. Then the mortality prediction score is covered into a biological age value (CDF.univariate(120,age)). Finally, you can solve the equation CDF(120,x) = CDF.univariate(120,age). I hope this helps. Please send me an email if it is not clear. Best, |
Hello,
As you can see from Levine 2018 (supplementary methods), the formula you attached is just a part of the equation. In order to fully solve the equation to get PhenoAge, you need to compute a mortality prediction score (CDF(120,x)) first. Then the mortality prediction score is covered into a biological age value (CDF.univariate(120,age)). Finally, you can solve the equation CDF(120,x) = CDF.univariate(120,age).
I hope this helps. Please send me an email if it is not clear.
Best,
Dayoon