diff --git a/contrib/guix/README.md b/contrib/guix/README.md
index f0ba490366aa4..177f01f8ebac2 100644
--- a/contrib/guix/README.md
+++ b/contrib/guix/README.md
@@ -22,6 +22,11 @@ Conservatively, you will need:
 If you don't have Guix installed and set up, please follow the instructions in
 [INSTALL.md](./INSTALL.md)
 
+Additionally the `guix-build` script will build a docker compatible image
+which require to install QEMU user static binary.
+
+On Debian you can install `qemu-user-static` package.
+
 # Usage
 
 If you haven't considered your security model yet, please read [the relevant
@@ -224,7 +229,7 @@ details.
 
   _(defaults to "x86\_64-linux-gnu arm-linux-gnueabihf aarch64-linux-gnu
   riscv64-linux-gnu powerpc64-linux-gnu powerpc64le-linux-gnu
-  x86\_64-w64-mingw32 x86\_64-apple-darwin arm64-apple-darwin")_
+  x86\_64-w64-mingw32 x86\_64-apple-darwin arm64-apple-darwin docker-x86\_64-linux docker-aarch64-linux")_
 
 * _**SOURCES_PATH**_
 
diff --git a/contrib/guix/docker/bitcoin-knots.scm b/contrib/guix/docker/bitcoin-knots.scm
new file mode 100644
index 0000000000000..edf9719f01556
--- /dev/null
+++ b/contrib/guix/docker/bitcoin-knots.scm
@@ -0,0 +1,73 @@
+(define-module (bitcoin-knots)
+  #:use-module ((guix licenses) #:prefix license:)
+  #:use-module (guix packages)
+  #:use-module (guix git-download)
+  #:use-module (guix build-system cmake)
+  #:use-module (guix gexp)
+  #:use-module (guix utils)
+  #:use-module (gnu packages)
+  #:use-module (gnu packages bash)
+  #:use-module (gnu packages base)
+  #:use-module (gnu packages boost)
+  #:use-module (gnu packages libevent)
+  #:use-module (gnu packages networking)
+  #:use-module (gnu packages pkg-config)
+  #:use-module (gnu packages python)
+  #:use-module (gnu packages python-xyz)
+  #:use-module (gnu packages sqlite))
+
+(define-public bitcoin-knots
+  (package
+    (name "bitcoin-knots")
+    (version (getenv "VERSION"))
+    ; the source section is overrided by the guix-build script
+    (source (origin
+              (method git-fetch)
+              (uri (git-reference
+                    (url "https://github.com/bitcoinknots/bitcoin")
+                    (commit (string-append "v" version))))
+              ; We use a fake hash because this scheme isn't supposed
+              ; to be builded outside the guix-build scipt
+              (sha256 #f)))
+    (build-system cmake-build-system)
+    (arguments
+     (list #:configure-flags
+           #~(list
+              "-DBUILD_GUI=OFF"
+              "-DBUILD_TESTS=ON"
+              "-DWITH_ZMQ=ON")
+           #:phases
+           #~(modify-phases %standard-phases
+               (add-before 'build 'set-no-git-flag
+                 (lambda _
+                   ;; Make it clear we are not building from within a git repository
+                   ;; (and thus no information regarding this build is available
+                   ;; from git).
+                   (setenv "BITCOIN_GENBUILD_NO_GIT" "1")))
+               (add-before 'check 'set-home
+                 (lambda _
+                   ;; Tests write to $HOME.
+                   (setenv "HOME" (getenv "TMPDIR")))))))
+    (native-inputs
+     (list bash ; provides the sh command for system_tests
+           coreutils ; provides the cat, echo and false commands for system_tests
+           pkg-config
+           python ; for the tests
+           python-pyzmq ; for the tests
+           ))
+    (inputs
+     (list boost
+           libevent
+           sqlite
+           zeromq))
+    (home-page "https://bitcoinknots.org/")
+    (synopsis "Bitcoin peer-to-peer client")
+    (description
+     "Bitcoin is a digital currency that enables instant payments to anyone
+anywhere in the world.  It uses peer-to-peer technology to operate without
+central authority: managing transactions and issuing money are carried out
+collectively by the network.  This package provides the Bitcoin Knots command
+line client.")
+    (license license:expat)))
+
+bitcoin-knots
diff --git a/contrib/guix/docker/channels.scm b/contrib/guix/docker/channels.scm
new file mode 100644
index 0000000000000..9dd5eace55a75
--- /dev/null
+++ b/contrib/guix/docker/channels.scm
@@ -0,0 +1,14 @@
+(define-module (channels))
+(use-modules (guix channels))
+
+(list (channel
+        (name 'guix)
+        (url "https://git.savannah.gnu.org/git/guix.git")
+        (branch "master")
+        (commit
+          "8eed773a70afa696b3b67ca49ee67257b8a44b03")
+        (introduction
+          (make-channel-introduction
+            "9edb3f66fd807b096b48283debdcddccfea34bad"
+            (openpgp-fingerprint
+              "BBB0 2DDF 2CEA F6A8 0D1D  E643 A2A0 6DF2 A33A 54FA")))))
diff --git a/contrib/guix/guix-build b/contrib/guix/guix-build
index f955124d014ec..c68ea7acf6bf4 100755
--- a/contrib/guix/guix-build
+++ b/contrib/guix/guix-build
@@ -82,7 +82,8 @@ check_source_date_epoch
 # Default to building for all supported HOSTs (overridable by environment)
 export HOSTS="${HOSTS:-x86_64-linux-gnu arm-linux-gnueabihf aarch64-linux-gnu riscv64-linux-gnu powerpc64-linux-gnu powerpc64le-linux-gnu
                        x86_64-w64-mingw32
-                       x86_64-apple-darwin arm64-apple-darwin}"
+                       x86_64-apple-darwin arm64-apple-darwin
+                       docker-x86_64-linux docker-aarch64-linux}"
 
 # Usage: distsrc_for_host HOST
 #
@@ -301,6 +302,12 @@ mkdir -p "$OUTDIR_BASE"
 # Download the depends sources now as we won't have internet access in the build
 # container
 for host in $HOSTS; do
+    case "$host" in
+        docker*)
+            # No need to download depends sources for docker builds
+            continue
+            ;;
+    esac
     make -C "${PWD}/depends" -j"$JOBS" download-"$(host_to_commonname "$host")" ${V:+V=1} ${SOURCES_PATH:+SOURCES_PATH="$SOURCES_PATH"}
 done
 
@@ -352,6 +359,33 @@ for host in $HOSTS; do
     # Display proper warning when the user interrupts the build
     trap 'int_trap ${host}' INT
 
+    if [[ "$host" == docker* ]]; then
+        mkdir -p "$OUTDIR_BASE/docker"
+    fi
+
+    case "$host" in 
+        docker*)
+            echo "Building docker image for ${host#docker-}"
+            dockerpath=$(VERSION="${VERSION}" \
+                guix time-machine -C ${PWD}/contrib/guix/docker/channels.scm -- \
+                pack -L "${PWD}"/contrib/guix/docker \
+                -f docker \
+                --system=${host#docker-} \
+                --entry-point=bin/bitcoind \
+                --with-git-url=bitcoin-knots=file://"${PWD}" \
+                bitcoin-knots \
+                | tee /dev/tty | tail -n1)
+            if [ ! -z "$dockerpath" ]; then
+                cp "$dockerpath" "$OUTDIR_BASE/docker/${DISTNAME}-${host}.tar.gz"
+                chmod 644 "$OUTDIR_BASE/docker/${DISTNAME}-${host}.tar.gz"
+                sha256sum "$OUTDIR_BASE/docker/${DISTNAME}-${host}.tar.gz" >> "$OUTDIR_BASE/docker/SHA256SUMS.part"
+            else
+                echo "Failed to build docker image for ${host#docker-}, exiting..."
+                exit 1
+            fi
+            continue
+            ;;
+        *)
     (
         # Required for 'contrib/guix/manifest.scm' to output the right manifest
         # for the particular $HOST we're building for
@@ -471,5 +505,6 @@ EOF
                                         DIST_ARCHIVE_BASE=/outdir-base/dist-archive \
                                       bash -c "cd /bitcoin && bash contrib/guix/libexec/build.sh"
     )
-
+        ;;
+        esac
 done