diff --git a/aws-opentelemetry-distro/src/amazon/opentelemetry/distro/code_correlation/internal/packages_resolver.py b/aws-opentelemetry-distro/src/amazon/opentelemetry/distro/code_correlation/internal/packages_resolver.py
index b2ad5c261..056b0e6f7 100644
--- a/aws-opentelemetry-distro/src/amazon/opentelemetry/distro/code_correlation/internal/packages_resolver.py
+++ b/aws-opentelemetry-distro/src/amazon/opentelemetry/distro/code_correlation/internal/packages_resolver.py
@@ -364,7 +364,8 @@ def is_third_party_package(file_path: Path) -> bool:
         return False
 
     third_party_packages = _load_third_party_packages()
-    return distribution.name in third_party_packages
+    # Perform case-insensitive comparison to handle packages like 'Django' vs 'django'
+    return distribution.name.lower() in third_party_packages
 
 
 @lru_cache(maxsize=1024)
diff --git a/aws-opentelemetry-distro/tests/amazon/opentelemetry/distro/code_correlation/internal/test_packages_resolver.py b/aws-opentelemetry-distro/tests/amazon/opentelemetry/distro/code_correlation/internal/test_packages_resolver.py
index d39806a6f..4b897eb44 100644
--- a/aws-opentelemetry-distro/tests/amazon/opentelemetry/distro/code_correlation/internal/test_packages_resolver.py
+++ b/aws-opentelemetry-distro/tests/amazon/opentelemetry/distro/code_correlation/internal/test_packages_resolver.py
@@ -577,6 +577,18 @@ def test_is_third_party_package_not_in_list(self, mock_load_packages, mock_resol
 
         self.assertFalse(result)
 
+    @patch("amazon.opentelemetry.distro.code_correlation.internal.packages_resolver.resolve_package_from_filename")
+    @patch("amazon.opentelemetry.distro.code_correlation.internal.packages_resolver._load_third_party_packages")
+    def test_is_third_party_package_case_insensitive_match(self, mock_load_packages, mock_resolve):
+        """Test case-insensitive detection of third-party package."""
+        # Test with uppercase package name in distribution but lowercase in third-party list
+        mock_resolve.return_value = Distribution(name="Django", version="4.2.0")
+        mock_load_packages.return_value = {"django", "requests", "urllib3"}
+
+        result = is_third_party_package(Path("/path/to/Django/__init__.py"))
+
+        self.assertTrue(result)
+
 
 class TestIsUserCode(TestCase):
     """Test the is_user_code function."""